ABERRANT GLYCANS ON CANCER CELLS
Targeting the sweet spot of Cancer
Breaking the glycan shield of solid tumors
Most cancer cells on solid tumors are characterized by the expression of antigens such as aberrant glycans that confer increased malignancy to the cells. This expression has been suggested to be associated with patients' low survival. Studies have shown that specific glycans induce an immunosuppressive phenotype on immune cells while cancer cells expressing these antigens present malignant features associated with poor prognosis and reduced overall survival.
These antigens are restricted to cancer cells, making these the most suitable targets when treating several types of solid tumors.